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KMID : 0364219840270030151
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Korean Journal of Zoology
1984 Volume.27 No. 3 p.151 ~ p.164
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The Effect of Muscle-Conditioned Medium on the Fusion of Chick Embryonic Myoblast Cells in Culture
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Ha Doo-Bong
Yoo Yung-Joon
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Abstract
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In order to investigate the mechanism of myoblast fusion during muscle differentiation in culture, the effect of muscle-conditioned medium on the fusion was studied and possible release from cultured myoblast cells of proteins which may be responsible for the promotion of myoblast fusion was analyzed. The muscle-conditioned medium showed a marked fusion-promoting activity in a dose-dependent fashion. THis fusion-promoting activity of the muscle-conditioned medium appeared to be due to the accumulation of at least two proteins which were released from the myoblast into the culture medium. These released proteins were analyzed by electrophoresis and autoradiography and found to have molecular weights of 45,000 and 65,000.
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KEYWORD
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